Animal Facility

Overview

The Animal Facility Shared Resource facilitates research through humane and efficient management of animal populations. The vivarium operates as a modified barrier facility and is equipped with quarantine and a procedure room, holding rooms with biosafety cabinets, an imaging/holding room equipped with a PerkinElmer IVIS SpectrumCT imaging system, and additional support areas. The Facility has rack space for more than 6,000 sterile, disposable, and individually ventilated mouse cages. Space for housing limited numbers of small animal species other than mice is also available upon request. Wistar’s Animal Care and Use Program, overseen by The Wistar Institutional Animal Care and Use Committee (IACUC), is fully accredited by AAALAC International since 1998, has an assurance on file with the Office of Laboratory Animal Welfare at the NIH, and is a registered USDA research institution.

Services

  • Laboratory animal medicine and husbandry
  • Animal procurement
  • Animal health surveillance
  • NSG colony maintenance and breeding
  • Veterinary care and pharmacy
  • Quarantine housing
  • Technical support and training
  • Mouse pathology
  • Transgenic Services in collaboration with Fox Chase Cancer Center

Equipment & Features

  • Ventilated, sterile, disposable caging system
  • Common use anesthesia, germinator and CO2 machines
  • In vivo imaging suite for small animal imaging equipped with a PerkinElmer IVIS SpectrumCT imaging system
  • Hydrogen peroxide decontamination chamber
  • Isolation cubicles
  • Procedure room

This facility is supported in part by a Cancer Center Support Grant (CCSG) awarded by the National Cancer Institute (NCI) to The Wistar Institute Cancer Center.

Contact Us

The Wistar Institute
Animal Facility, Rooms G75-78
3601 Spruce Street
Philadelphia, PA 19104

Facility office hours: 
8:00 a.m. – 4:30 p.m., Monday-Friday

 

Andrew Caton, Ph.D.
Scientific Director

Denise DiFrancesco, AS, RLATG, CMAR, ILAM
Managing Director
Phone: 215-898-3782

Marci Houston Leslie, BA, LAT
Supervisor/Animal Health Coordinator
Phone: 215-898-3780

Mouse Pathology

David Garlick, D.V.M., a board-certified veterinary pathologist and expert in mouse histopathology and embryology, provides consultation and scientific collaboration. Services include: project consultation, histology slide evaluation and report preparation, and image development. Mouse pathology services are free for Wistar Cancer Center members. To request services, email Dr. Garlick at dgarlick@hsrl.org. Provide a detailed summary of your experimental protocol, key experimental questions, and material to be provided.

Transgenic Services

Wistar maintains an inter-institutional agreement with Fox Chase Cancer Center to generate transgenic and genetically modified mice utilizing services and expertise of both Fox Chase Transgenic Mouse Facility Staff and Wistar Animal Facility staff.