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The four distinct yet complementary research programs in The Wistar Institute Cancer Center are the Gene Expression and Regulation program, the Molecular and Cellular Oncogenesis program, the Tumor Microenvironment and Metastasis program, and the Translational Tumor Immunology program.

Gene Expression and Regulation

Aim: To explore cancer and other diseases at the level of individual genes and gene systems, including investigations of the molecular mechanisms of gene regulation.

Molecular and Cellular Oncogenesis

Aim: To understand cell signaling in tumorigenesis, metastasis and cell differentiation and to use biological and systems biological approaches to develop new strategies for cancer diagnosis and therapy.

Immunology, Microenvironment and Metastasis

Aim: To understand how stromal, inflammatory and endothelial components of the tumor mass play a pivotal role in disease maintenance, progression and dissemination while also investigating the mechanisms regulating immune responses and their potential therapeutic manipulation.