Yulia Nefedova, M.D., Ph.D.

Yulia Nefedova, M.D., Ph.D.

Laboratory

The Nefedova Laboratory

Contact

215-495-6952
ynefedova@wistar.org

Associate Professor, Immunology, Microenvironment & Metastasis Program

About the Scientist

Nefedova studies molecular mechanisms by which bone marrow microenvironment promotes tumor survival and progression.

Nefedova obtained her M.D. and Ph.D. degrees at the Pavlov First State Medical University of St. Petersburg, Russia. She then pursued postdoctoral training at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, FL, where she began her research in multiple myeloma. In 2013, Dr. Nefedova has joined The Wistar Institute as an assistant professor in the Tumor Microenvironment and Metastasis program, and 2017, she was promoted to an associate professor in the Immunology, Microenvironment and Metastasis program.

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The Nefedova Laboratory

The Nefedova laboratory focuses on understanding the role of bone marrow microenvironment in regulation of tumor progression and therapy resistance. The laboratory primarily studies multiple myeloma, a cancer of plasma cells. Multiple myeloma preferentially localizes in the bone marrow where the majority of surrounding cells are represented by mature and immature neutrophils.

The laboratory is interested in mechanisms by which interactions between neutrophils and multiple myeloma cells promote disease progression and chemoresistance. Neutrophils are able to form neutrophils extracellular traps (NETs), structures composed of chromatin and neutrophil proteins. The implication of NETs in myeloma progression and targeting a process of NET formation for treatment of multiple myeloma are under investigation. The laboratory is also interested in the role of S100A9 protein, highly expressed by neutrophils, in hematopoiesis as well as in its involvement in pathogenesis of multiple myeloma.

Staff

Postdoctoral Fellows

Sarah Herlihy, Ph.D.
Cindy Lin, Ph.D.

Predoctoral Trainee

Marina Li

Research Assistant

Maria Ozerova, Ph.D.