The Nefedova Laboratory
The Nefedova laboratory focuses on understanding the role of bone marrow microenvironment in regulation of tumor progression and therapy resistance. The laboratory primarily studies multiple myeloma, a cancer of plasma cells. Multiple myeloma preferentially localizes in the bone marrow where the majority of surrounding cells are represented by mature and immature neutrophils.
The laboratory is interested in mechanisms by which interactions between neutrophils and multiple myeloma cells promote disease progression and chemoresistance. Neutrophils are able to form neutrophils extracellular traps (NETs), structures composed of chromatin and neutrophil proteins. The implication of NETs in myeloma progression and targeting a process of NET formation for treatment of multiple myeloma are under investigation. The laboratory is also interested in the role of S100A9 protein, highly expressed by neutrophils, in hematopoiesis as well as in its involvement in pathogenesis of multiple myeloma.
Sarah Herlihy, Ph.D.
Cindy Lin, Ph.D.
Maria Ozerova, Ph.D.