The Nefedova Laboratory
The Nefedova laboratory focuses on understanding the role of bone marrow microenvironment in regulation of tumor progression and therapy resistance. The laboratory primarily studies multiple myeloma, a cancer of plasma cells. Multiple myeloma preferentially localizes in the bone marrow where the majority of surrounding cells are represented by mature and immature neutrophils.
The laboratory is interested in mechanisms by which interactions between neutrophils and multiple myeloma cells promote disease progression and chemoresistance. Neutrophils are able to form neutrophils extracellular traps (NETs), structures composed of chromatin and neutrophil proteins. The implication of NETs in myeloma progression and targeting a process of NET formation for treatment of multiple myeloma are under investigation. The laboratory is also interested in the role of S100A9 protein, highly expressed by neutrophils, in hematopoiesis as well as in its involvement in pathogenesis of multiple myeloma.
Sarah Herlihy, Ph.D.
Cindy Lin, Ph.D.
Maria Ozerova, Ph.D.
Herlihy, S.E., Lin, C., Nefedova, Y. "Bone marrow myeloid cells in regulation of multiple myeloma progression." Cancer Immunol Immunother. 2017 Aug;66(8):1007-1014. doi: 10.1007/s00262-017-1992-0. Epub 2017 Apr 4.
Condamine, T., Dominguez, G.A., Youn, J.I., Kossenkov, A.V., Mony, S., Alicea-Torres, K., Tcyganov, E., Hashimoto, A., Nefedova, Y., Lin, C., Partlova, S., Garfall, A., Vogl, D.T., Xu, X., Knight, S.C., Malietzis, G., Lee, G.H., Eruslanov, E., Albelda, S.M., Wang, X., Mehta, J.L., Bewtra, M., Rustgi, A., Hockstein, N., Witt, R., Masters, G., Nam, B., Smirnov, D., Sepulveda, M.A., Gabrilovich, D.I. "Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients." Sci Immunol. 2016 Aug;1(2). pii: aaf8943. doi: 10.1126/sciimmunol.aaf8943. Epub 2016 Aug 5.
Tang, C.H., Zundell, J.A., Ranatunga, S., Lin, C., Nefedova, Y., Del Valle, J.R., Hu, C.C. "Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells." Cancer Res. 2016 Apr 15;76(8):2137-52. doi: 10.1158/0008-5472.CAN-15-1885. Epub 2016 Mar 7.
Pisklakova, A., Grigson, E., Nefedova, Y., et al. "Anti-myeloma effect of pharmacological inhibition of Notch/gamma-secretase with RO4929097 is mediated by modulation of tumor microenvironment." Cancer Biol Ther. 2016 May 3;17(5):477-85. doi: 10.1080/15384047.2016.1156261. Epub 2016 Mar 2.
Ramachandran, I.R., Condamine, T., Nefedova, Y., et al. "Bone marrow PMN-MDSCs and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy." Cancer Lett. 2016 Feb 1;371(1):117-24. doi: 10.1016/j.canlet.2015.10.040. Epub 2015 Nov 27.