The Liu Laboratory
The Liu laboratory applies biostatistics to several areas of research, including: basic cancer research and clinical trials of cancer immunotherapy; infectious diseases; behavioral and educational intervention research; and research on health care outcomes.
Xiangfan Yin, M.S.
Han Wang, Ph.D.
The Biostatistics Unit supervised by Liu provides in-house biostatistics expertise to accommodate continuing growth in translational and pre-clinical cancer research. This Unit provides statistical support to biological laboratories at Wistar and its tasks include, but not limited to, large data management, experiment design, statistical data analysis, data presentation for manuscripts and grant proposal development. Liu has extensive experience working with basic and clinical investigators on statistical issues. Her strong statistical and biomedical backgrounds have enabled her to provide exceptionally high levels of scientific input to different projects. As a result, her effort has contributed to many published papers and funded grant proposals for clinical and basic science investigators. Within a short time after she joined The Wistar Institute, she engaged in a plethora of collaborative projects with Wistar Cancer Center members and obtained joint NIH funding with inside and outside Wistar investigators, including two P01 Program Project grants on novel molecular therapies of prostate cancer and melanoma targeted therapies. There is significant institutional support for collaborative efforts between the Biostatistics Unit and the investigators at Wistar.
Liu, Q., Yin, X., Languino, L.R., Altieri, D.C. "Evaluation of drug combination effect using a Bliss independence dose-response surface model." Statistics in Biopharmaceutical Research 2018.10:2, 112-122, DOI: 10.1080/19466315.2018.1437071.
Giron, L.B., Azzoni, L., Yin, X., Lynn, K.M., Ross, B.N., Fair, M., Damra, M., Sciorillo, A.C., Liu, Q., Jacobson, J.M., Mounzer, K., Kostman, J.R., Abdel-Mohsen, M., Montaner, L.J., Papasavvas, E. "Hepatitis C virus modulates IgG glycosylation in HIV co-infected antiretroviral therapy suppressed individuals." AIDS. 34(10): 1461-1466, Jul 2020.
Li, J., Agarwal, E., Bertolini, I., Seo, J.H., Caino, M.C., Ghosh, J.C., Kossenkov, A.V., Liu, Q., Tang, X-Y, Goldman, A.R., Languino, L.R., Speicher, D.W., Altieri, D.C. "The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells." Science Signaling. 2020; 13 (642), e aaz8240, DOI: 10.1126/scisignal.aaz8240.
Krishn, S.R., Salem, I., Quaglia, F., Naranjo, N., Agarwal, E., Liu, Q., Sarker, S., Kopenhaver, J., McCue, P.A., Weinreb, P.H., Violette, S.M., Altieri, D.C., Languino, L.R. "The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis." Journal of extracellular vesicles. 2020; 9:1, 1763594, DOI: 10.1080/20013078.2020.1763594
Singh, K.S., Leu, J.I., Barnoud, T., Vonteddu, P., Gnanapradeepan, K., Lin, C., Liu, Q., Barton, J.C., Kossenkov, A.V., George, D.L., Murphy, M.E., Dotiwala, F. "African-centric variant in TP53 is associated with increased iron accumulation and bacterial pathogenesis but improved response to malaria toxin." Nature Communications. 2020 Jan 24;11(1):473. doi: 10.1038/s41467-019-14151-9. PMID: 31980600. PMCID: PMC6981190.
Paul M. Lieberman, Ph.D.
Hilary Koprowski, M.D., Endowed Professor and Program Leader, Gene Expression & Regulation Program, The Wistar Institute Cancer Center
Director, Center for Chemical Biology & Translational Medicine
Luis J. Montaner, D.V.M., D.Phil.
Vice President, Scientific Operations
Associate Director for Shared Resources, The Wistar Institute Cancer Center
Herbert Kean, M.D., Family Endowed Chair Professor; Director, HIV-1 Immunopathogenesis Laboratory and Leader, HIV Research Program, Vaccine & Immunotherapy Center;
Immunology, Microenvironment & Metastasis Program, The Wistar Institute Cancer Center