Lab In The News
The Wistar Institute Recruits Vaccine Researcher Amelia Escolano, Ph.D., and Immunologist Nan Zhang, Ph.D., as Assistant ProfessorsPHILADELPHIA — (Sept. 1, 2021) — The Wistar Institute, an international biomedical research leader in cancer, immunology and infectious diseases, welcomes Amelia Escolano, Ph.D., and Nan Zhang, Ph.D., as assistant professors.
Studying Immunology and Cancer, Nan Zhang, Ph.D., Delves Into Mysteries Of Ovarian Cancer Metastasis
Few biologists can say they saw a type of cells for the first time. Nan Zhang, Ph.D., who started at The Wistar Institute in September as an assistant professor, became one of those biologists when, during his postdoctoral research at Washington University in St. Louis, he peered through a...
The Zhang Lab
Macrophages are currently considered as highly heterogenous and plastic with different developmental origins and microenvironmental signatures.
The Zhang lab focuses on understanding how macrophages regulate tumor growth and metastasis in the peritoneal space. We use single-cell sequencing, ATAC sequencing, large-scale imaging, multiphoton intravital imaging, novel genetic mouse models, and patient samples to understand how different subsets of macrophages function differently in mice and in humans. Our long-term goal is to develop novel macrophage-based immunotherapies to treat peritoneal cancers.
Brennah Murphy, Ph.D.
Taito Miyamoto, Ph.D.
Bryan Manning (USciences)
Postdoctoral fellow/research assistant positions are available in the Zhang laboratory with a research focus on peritoneal immunity against carcinomatosis using mouse models.
Candidates should have recently received or be close to obtaining their Ph.D. degree or equivalent (for postdoc) or B.S. degree or equivalent (for RA) and have a strong background in one or more of the following disciplines: immunology, tumor microenvironment, biochemistry, and molecular biology. Interested applicants are invited to email firstname.lastname@example.org.
Current projects in the lab include:
- Heterogeneity and origins of macrophages during peritoneal carcinomatosis.
- Activation of macrophages against tumor progression.
- Tissue-specific functions and microenvironment of peritoneal macrophages.
Zhang, N., Kim, S. H., Gainullina, A., Erlich, E.C., Onufer, E.J., Kim, J., Czepielewski, R.S., Helmink, B.A., Dominguez, J.R., Saunders, B.T., et al. “LYVE1+ Macrophages Of Murine Peritoneal Mesothelium Promote Omentum-independent Ovarian Tumor Growth.” J Exp Med. 2021 Dec 6;218(12):e20210924. doi: 10.1084/jem.20210924. Epub 2021 Oct 29.
Zhang, N., Czepielewski, R.S., Jarjour, N.N. , Erlich, E.C., Esaulova, E., Saunders, B.T., Grover, S.P., Cleuren, A.C., Broze, G.J., Edelson, B.T., et al. “Expression Of Factor V By Resident Macrophages Boosts Host Defense In The Peritoneal Cavity.” J Exp Med. 2019 Jun 3;216(6):1291-1300. doi: 10.1084/jem.20182024. Epub 2019 May 2.
Kim K.W., Zhang N., Choi K., Randolph G.J. “Homegrown Macrophages.” Immunity. 2016 Sep 20;45(3):468-470. doi: 10.1016/j.immuni.2016.09.006.
Liu, Z., Yago, T., Zhang, N., Panicker, S.R., Wang, Y., Yao, L., Mehta-D’souza, P., Xia, L., Zhu, C., McEver, R.P. “L-selectin Mechanochemistry Restricts Neutrophil Priming In Vivo.” Nat Commun. 2017 May 12;8:15196. doi: 10.1038/ncomms15196.
Yago, T., Petrich, B.G., Zhang, N., Liu, Z., Shao, B., Ginsberg, M.H., McEver, R.P. “Blocking Neutrophil Integrin Activation Prevents Ischemia-reperfusion Injury.” J Exp Med. 2015 Jul 27;212(8):1267-81. doi: 10.1084/jem.20142358. Epub 2015 Jul 13.
David B. Weiner, Ph.D.
Executive Vice President
Director, Vaccine & Immunotherapy Center
W.W. Smith Charitable Trust Professor in Cancer Research, Immunology, Microenvironment & Metastasis Program, Ellen and Ronald Caplan Cancer Center
Professor Emeritus, University of Pennsylvania School of Medicine