Lab In The News
Spotlight on Wistar COVID-19 Researchers: Luis Montaner, D.V.M., D.Phil., & Joseph Salvino, Ph.D.
Dr. Luis Montaner is an HIV expert focused on finding new ways to boost the natural function of the immune system to combat infection or viral-associated disease. Dr.
The Salvino Laboratory
Salvino’s research is directed at drug discovery and development. His laboratory focuses on early drug discovery and small molecule tool compounds for in vivo target validation to confirm the pharmacological relevance and “drugability” of a therapeutic target. Medicinal chemistry optimization is focused on the design and creation of new chemical analogs to understand structure activity relationships (SARS) critical for optimizing an early stage compound series. This effort is important to help identify a potential preclinical drug candidate or future therapeutic agent against a new biological target.
Salvino is the Scientific Director of the Molecular Screening & Protein Expression Shared Resource which closely aligns screening capabilities for lead optimization and hit-to-lead activities that are ongoing in his laboratory.
Current projects include development of HSP70 inhibitors, compounds blocking HIV and other antivirals, glutamate transporter (EAAT2) stimulators, Proteolysis Targeting Chimeras (PROTACs), small molecules targeting protein-protein interactions, chemical probes for assay development, and cancer or tissue targeting pro-drugs.
Valli Venkata Srikanth Yellamelli, Ph.D.
Adi Narayana Reddy Poli, Ph.D.
Farheen Mohammed, Ph.D.
Jitendra Gour, Ph.D.
Irfan Khan, Ph.D.
Dominici, M.D., Porazzi, P., Xiao, Y., Chao, A., Tang, H., Kumar, G., Fortina, P., Spinelli, O., Rambaldi, A., Peterson, L.F., et al. "Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs." Blood. 2020 Apr 30;135(18):1560-1573. doi: 10.1182/blood.2019003604.
Walden, M., Tian, L., Ross, R.L., Sykora, U.M., Byrne, D.P., Hesketh, E.L., Masandi, S.K., Cassel, J., George, R., Ault, J.R., et al. "Metabolic control of BRISC-SHMT2 assembly regulates immune signalling." Nature. 2019 Jun;570(7760):194-199. doi: 10.1038/s41586-019-1232-1. Epub 2019 May 29.
Falcucci , R.M., Wertz, R., Green, J.L., Meucci, O., Salvino, J., Fontana, A.C.K. "Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model." ACS Chem Neurosci. 2019 Aug 21;10(8):3437-3453. doi: 10.1021/acschemneuro.9b00061. Epub 2019 Jul 11.
Salvino, J.M., Srikanth, Y.V.V., Lou, R., Oyer, H.M., Chen, N., Kim, F.J., et al. "Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer." Bioorg Med Chem Lett. 2017 May 15;27(10):2216-2220. doi: 10.1016/j.bmcl.2017.03.030. Epub 2017 Mar 18.
Tikhmyanova, N., Paparoidamis, N., Romero-Masters, J., Feng, X., Mohammed, F.S., Reddy, P.A.N., Kenney, S.C., Lieberman, P.M., Salvino, J.M. "Development of a Novel Inducer for EBV Lytic Therapy." Bioorg Med Chem Lett. 2019 Aug 15;29(16):2259-2264. doi: 10.1016/j.bmcl.2019.06.034. Epub 2019 Jun 22.