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Jesper Pallesen, MBA, Ph.D.

  • Assistant Professor, Vaccine & Immunotherapy Center

Pallesen received his Ph.D. degree from Aarhus University. He received his postdoctoral training at Columbia University and The Scripps Research Institute. Here, he specialized in cryo-electron microscopy of bio-molecular protein complexes relating to infectious disease and immunobiology. In parallel to his postdoctoral training, he has extensive experience as a technical consultant in IP law and he received his M.B.A. from Rady School of Management with specialization in statistics, finance and management. His group studies infectious disease and cancer and develops vaccines and immunotherapeutics from a structural biology guided approach.

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The Pallesen Laboratory

215-898-3941
jpallesen@wistar.org

The Pallesen Laboratory

Staff
  • Graduate Students

    Jianqiu Du, M.S.
    Jiayan Cui
    ZiJie (Jerry) Lin

The Pallesen Lab in the News

Selected Publications

DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2.

Parzych EM, Du J, Ali AR, Schultheis K, Frase D, Smith TRF, Cui J, Chokkalingam N, Tursi NJ, Warner BM, Gary EN, Li Y, Choi J, Eisenhauer J, Maricic I, Kulkarni A, Chu J, Villafana G, Rosenthal K, Ren K, Francica JR, Wootton S, Tebas P, Kobasa D, Broderick K, Boyer JD, Esser MT, Pallesen J, Kulp DW, Patel A, Weiner DB. “DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2.” Nat. Commun. 2022 Oct 6;13(1):5886.

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template.

Andrabi R*, Pallesen J*, Allen JD, Song G, Zhang J, de Val N, Gegg G, Porter K, Su CY, Pauthner M, Newman A, Bouton-Verville H, Garces F, Wilson IA, Crispin M, Hahn BH, Haynes BF, Verkoczy L, Ward AB, Burton DR. “The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template.” Cell Rep. 2019 May 21;27(8):2426-2441.e6.

Immunogenicity and Structures of a Rationally Designed Prefusion MERS-CoV Spike Antigen.

Pallesen J*, Wang N*, Corbett KS*, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong W, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS. “Immunogenicity and Structures of a Rationally Designed Prefusion MERS-CoV Spike Antigen.” Proc Natl Acad Sci USA. 2017 Aug 29;114(35):E7348-E7357.

Open and Closed Structures Reveal Allostery and Pliability in the HIV-1 Envelope Spike.

Ozorowski G*, Pallesen J*, de Val N, Lyumkis D, Cottrell CA, Torres JL, Copps J, Stanfield RL, Cupo A, Pugach P, Moore JP, Wilson IA, Ward AB. “Open and Closed Structures Reveal Allostery and Pliability in the HIV-1 Envelope Spike.” Nature. 2017 Jul 20;547(7663):360-363.

Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies.

Pallesen J*, Murin CD*, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE Jr, Saphire EO, Ward AB. “Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies.” Nat Microbiol. 2016;1 pii: 16128. Epub 2016 Aug 8.

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