Lab In The News
How to ruin cancer’s day
As a leading authority on cancer metabolism, Chi Van Dang, Ph.D. is routinely asked to speak about how tumors reprogram biochemical pathways to help them slurp up nutrients and how disrupting these noxious adaptations could be a powerful approach to treating cancer.
Dr. Chi Van Dang Ranks in the 2020 Highly Cited Researchers ListDr. Dang, a world-renowned scientist, medical oncologist, National Academy of Medicine member, and professor in Wistar’s Molecular and Cellular Oncogenesis Program, was selected for the 2020 Highly Cited Researchers list compiled by Clarivate Analytics.
The Dang Laboratory
The Dang laboratory has contributed to the understanding of the function of the MYC cancer gene, which has emerged as a central transcription factor or gene switch in many different human cancers. His laboratory established the first mechanistic link between the MYC cancer gene and cellular energy metabolism, contributing to the concept that genetic alterations in cancers re-program fuel utilization by tumors and render cancers addicted to certain fuel sources. His laboratory is now exploiting these concepts for therapeutic targeting of cancer cell metabolism as a new way to treat cancer. Ongoing interests of the Dang lab include MYC oncogene function in rewiring metabolism, the effects of oncogene and hypoxic stress on the circadian molecular clock, MYC oncogene effects on metabolism and immunity and MYC and metabolic vulnerabilities of cancers.
Hongguang Shao, Ph.D.
Associate Staff Scientist
Zachary Stine, Ph.D.
Adam Wolpaw, M.D. (attending pediatrician, CHOP)
Xue Zhang, Ph.D.
Brian J. Altman, Ph.D.
Assistant Professor, Department of Biomedical Genetics
Associate Member, Wilmot Cancer Institute
University of Rochester Medical Center
Zandra E. Walton, M.D., Ph.D.
Medical Resident, Massachusetts General Hospital
Zachary Stine, Ph.D.
Barer Institute, Rafael Holdings, Inc.
Hsieh, A.L., Zheng, X., Yue, Z., Stine, Z.E., Mancuso, A., Rhoades, S.E., Brooks, R., Weljie, A.M., et al. "Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism." Cell Rep. 2019 Nov 12;29(7):1778-1788.e4. doi: 10.1016/j.celrep.2019.10.022.
Gouw, A.M., Margulis, K. Liu, N.S., Raman, S.J., Mancuso, A., Toal, G.G., Tong, L., Mosley, A., Hsieh, A.L., Sullivan, D.K., et al. "The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth." Cell Metab. 2019 Sep 3;30(3):556-572.e5. doi: 10.1016/j.cmet.2019.07.012. Epub 2019 Aug 22.
Walton, Z.E., Patel, C.H., Brooks, R.C., Yu, Y., Ibrahim-Hashim, A., Riddle, M., Porcu, A., Jiang, T., Ecker, B.L., Tameire, F., et al. “Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.” Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31.
Rajeshkumar, N.V., Yabuuchi, S., Pai, S.G., Oliveira, E.D., Kamphorst, J.J., Rabinowitz, J.D., Tejero, H. , Al-Shahrour, F., Hidalgo, M., Maitra, A. "Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin." Clin Cancer Res. 2017 Sep 15;23(18):5639-5647. doi: 10.1158/1078-0432.CCR-17-1115. Epub 2017 Jun 13.
Altman, B.J., Hsieh, A.L., Sengupta, A., Krishnanaiah, S.Y., Stine, Z.E., Walton, Z.E., Gouw, A.M., Venkataraman, A., Li, B., Goraksha-Hicks, P. "MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells." Cell Metab. 2015 Dec 1;22(6):1009-19. doi: 10.1016/j.cmet.2015.09.003. Epub 2015 Sep 17.