Lab In The News
How to ruin cancer’s day
As a leading authority on cancer metabolism, Chi Van Dang, Ph.D. is routinely asked to speak about how tumors reprogram biochemical pathways to help them slurp up nutrients and how disrupting these noxious adaptations could be a powerful approach to treating cancer.
The Dang Laboratory
The Dang laboratory has contributed to the understanding of the function of the MYC cancer gene, which has emerged as a central transcription factor or gene switch in many different human cancers. His laboratory established the first mechanistic link between the MYC cancer gene and cellular energy metabolism, contributing to the concept that genetic alterations in cancers re-program fuel utilization by tumors and render cancers addicted to certain fuel sources. His laboratory is now exploiting these concepts for therapeutic targeting of cancer cell metabolism as a new way to treat cancer. Ongoing interests of the Dang lab include MYC oncogene function in rewiring metabolism, the effects of oncogene and hypoxic stress on the circadian molecular clock, MYC oncogene effects on metabolism and immunity and MYC and metabolic vulnerabilities of cancers.
Hongguang Shao, Ph.D.
Associate Staff Scientist
Zachary Stine, Ph.D.
Adam Wolpaw, M.D. (attending pediatrician, CHOP)
Xue Zhang, Ph.D.
Walton, Z.E., Patel, C.H., Brooks, R.C., Yu, Y., Ibrahim-Hashim, A., Riddle, M., Porcu, A., Jiang, T., Ecker, B.L., Tameire, F., et al. “Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.” Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31.
Lu, Y., Hu, Z., Mangala, L.S., Stine, Z.E., Hu, X., Jiang, D., Xiang, Y., Zhang, Y., Pradeep, S., Rodriguez-Aguayo, C., et al. "MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels." Cancer Res. 2018 Jan 1;78(1):64-74. doi: 10.1158/0008-5472.CAN-17-0815. Epub 2017 Nov 27.
Altman, B.J., Hsieh, A.L., Gouw, A.M., Dang, C.V. “Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα.” Nat Commun. 2017 Mar 23;8:14862. doi: 10.1038/ncomms14862.
Altman, B.J., Hsieh, A.L., Sengupta, A., Krishnanaiah, S.Y., Stine, Z.E., Walton, Z.E., Gouw, A.M., Venkataraman, A., Li, B., Goraksha-Hicks, P. "MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells." Cell Metab. 2015 Dec 1;22(6):1009-19. doi: 10.1016/j.cmet.2015.09.003. Epub 2015 Sep 17.
Xiang, Y., Stine, Z.E., Xia, J., Lu, Y., O'Connor, R.S., Altman, B.J., Hsieh, A.L., Gouw, A.M., Thomas, A.G., Gao, P. "Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis." J Clin Invest. 2015 Jun;125(6):2293-306. doi: 10.1172/JCI75836. Epub 2015 Apr 27.