Chi Van Dang, M.D., Ph.D.

Chi Van Dang, M.D., Ph.D.

Laboratory

The Dang Laboratory

Contact

215-898-3956
cdang@wistar.org

Professor, Molecular & Cellular Oncogenesis Program, The Wistar Institute Cancer Center

Strategic Advisor to the President

About the Scientist

Dang helped define the complex functions of the MYC oncogene, a central switch in human cancer, identifying key domains mediating Myc transcription factor activity.

Dang received his B.S. in Chemistry from the University of Michigan, Ann Arbor and Ph.D. in Chemistry from Georgetown University, Washington, DC. He earned an M.D. degree from the Johns Hopkins University School of Medicine, and was an Osler Medical Resident at Johns Hopkins Hospital. He received Hematology-Oncology training at UCSF, where he first worked on MYC, and returned to Johns Hopkins as Assistant Professor of Medicine.

Dang is Scientific Director of the Ludwig Institute for Cancer Research and joined The Wistar Institute as a Professor in July of 2017. He is a member of the National Academy of Medicine and a fellow of the American Academy of Arts & Sciences, and previously served as director of the Abramson Cancer Center, University of Pennsylvania.

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The Dang Laboratory

The Dang laboratory has contributed to the understanding of the function of the MYC cancer gene, which has emerged as a central transcription factor or gene switch in many different human cancers.  His laboratory established the first mechanistic link between the MYC cancer gene and cellular energy metabolism, contributing to the concept that genetic alterations in cancers re-program fuel utilization by tumors and render cancers addicted to certain fuel sources. His laboratory is now exploiting these concepts for therapeutic targeting of cancer cell metabolism as a new way to treat cancer. Ongoing interests of the Dang lab include MYC oncogene function in rewiring metabolism, the effects of oncogene and hypoxic stress on the circadian molecular clock, MYC oncogene effects on metabolism and immunity and MYC and metabolic vulnerabilities of cancers.

Staff

Staff Scientist

Hongguang Shao, Ph.D.

Associate Staff Scientist

Zachary Stine, Ph.D.

Postdoctoral Fellows

Adam Wolpaw, M.D. (attending pediatrician, CHOP)
Xue Zhang, Ph.D.

Predoctoral Trainees

Rebekah Brooks
Yaoyu Gong

Research Assistants

Patricia Brafford
May Dong
Darya Volgina

ALUMNI

Brian J. Altman, Ph.D.
Assistant Professor, Department of Biomedical Genetics
Associate Member, Wilmot Cancer Institute
University of Rochester Medical Center
Rochester, NY

Zandra E. Walton, M.D., Ph.D.
Medical Resident, Massachusetts General Hospital
Harvard University
Boston, MA

Zachary Stine, Ph.D.
Senior Scientist
Barer Institute, Rafael Holdings, Inc.
Philadelphia, PA
 

Selected Publications

Hsieh, A.L., Zheng, X., Yue, Z., Stine, Z.E., Mancuso, A., Rhoades, S.E., Brooks, R., Weljie, A.M., et al. "Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism." Cell Rep. 2019 Nov 12;29(7):1778-1788.e4. doi: 10.1016/j.celrep.2019.10.022.

Gouw, A.M., Margulis, K. Liu, N.S., Raman, S.J., Mancuso, A., Toal, G.G., Tong, L., Mosley, A., Hsieh, A.L., Sullivan, D.K., et al. "The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth." Cell Metab. 2019 Sep 3;30(3):556-572.e5. doi: 10.1016/j.cmet.2019.07.012. Epub 2019 Aug 22.

Walton, Z.E., Patel, C.H., Brooks, R.C., Yu, Y., Ibrahim-Hashim, A., Riddle, M., Porcu, A., Jiang, T., Ecker, B.L., Tameire, F., et al. “Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.” Cell. 2018 Jun 28;174(1):72-87.e32. doi: 10.1016/j.cell.2018.05.009. Epub 2018 May 31.

Rajeshkumar, N.V., Yabuuchi, S., Pai, S.G., Oliveira, E.D., Kamphorst, J.J., Rabinowitz, J.D., Tejero, H. , Al-Shahrour, F., Hidalgo, M., Maitra, A. "Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin." Clin Cancer Res. 2017 Sep 15;23(18):5639-5647. doi: 10.1158/1078-0432.CCR-17-1115. Epub 2017 Jun 13.

Altman, B.J., Hsieh, A.L., Sengupta, A., Krishnanaiah, S.Y., Stine, Z.E., Walton, Z.E., Gouw, A.M., Venkataraman, A., Li, B., Goraksha-Hicks, P. "MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells." Cell Metab. 2015 Dec 1;22(6):1009-19. doi: 10.1016/j.cmet.2015.09.003. Epub 2015 Sep 17.

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