Our Science

Erica Stone, Ph.D.

Erica Stone, Ph.D.

  • Assistant Professor, Translational Tumor Immunology Program
  • 215-495-6942, Office
  • estone@wistar.org
Summary

The laboratory of Erica L. Stone is investigating T cell biology in the context of specific microenvironments. Currently, the Stone Laboratory is focusing on the influence of tumor microenvironments and the digestive tract on T cell biology. The long-term goal of the lab is to exploit an understanding of the effect of microenvironments on T cell biology to treat diseases including cancer.

Dr. Stone came to Wistar as an Assistant Professor in 2015 from the University of California San Diego. Dr. Stone studied Biology as an undergraduate at the University of New Hampshire and went on to earn a Ph.D. in Biology at the University of California San Diego in 2009. During her Ph.D. she studied glycoimmunology. She then studied T cell biology as a Postdoctoral Fellow in the laboratory of Steve Hedrick at the University of California San Diego. In the Hedrick Laboratory, Dr. Stone studied the regulation of T cell differentiation and function by the transcription factor FOXO1 and began to investigate the mutual regulation of immunity and metabolism.

Potential Rotation Projects include:

1. Investigate potential mechanisms that prevent checkpoint blockade efficacy in a subset of patients – and therapeutic strategies to improve efficacy in these patients.
2. Investigate potential new cancer immunotherapeutic targets.
3. Investigate the effect of the mucosal glycoproteins on oral tolerance induction and mucosal immunity.
4.Investigate factors that influence oral tolerance through mucosal glycoproteins.

Selected Publications

1. Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Lin YC, Yang E, Goldrath AW, Li MO, Hedrick SM. Control of T follicular helper cell differentiation by FOXO1. Immunity. (2015), 42:239-51.
2Hedrick SM, Hess Michelini R, Doedens AL, Goldrath AW, Stone EL. FOXO transcription factors throughout T cell biology. Nat. Rev. Immunol. (2012), 12: 649-41.
3. Kerdiles YM*, Stone EL*, Beisner DR, McGargill MA, Ch’en IL, Stockmann C, Katayama CD, Hedrick SM. Foxo transcription factors control regulatory T cell development and function. Immunity (2010), 33: 890-904.
4. Ismail MN, Stone EL, Panico M, Lee SH, Luu Y, Ramirez K, Ho SB, Fukuda M, Marth JD, Haslam SM and Dell A. High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases. Glycobiology (2011), 21: 89-98.
5. Stone EL, Ismail MN, Lee SH, Luu Y, Ramirez K, Haslam SM, Ho SB, Dell A, Fukuda M and Marth JD. Glycosyltransferase Function in Core 2-Type Protein O-Glycosylation. Mol. Cell. Biol. (2009), 29:2770-82.

*co-first authors. My major contribution to this study was showing that FOXO1 is required for regulatory T cell function in vivo. Highlighted in a Preview in Immunity.