The EGR1 transcription factor has distinct roles in early and late macrophage maturation stages, blunting macrophage activation and inflammation.
Tumor-infiltrating mast cells are connected to immune checkpoint inhibitor resistance in melanoma.
Loss of ARID1A causes increased glutamine metabolism, which can be blocked pharmacologically to target ARID1A-mutant tumors.
New small molecule inhibitor impairs cancer growth in preclinical models by depriving malignant cells of a critical nutrient source.
Dual-acting immuno-antibiotics block an essential pathway in bacteria and activate the adaptive immune response.
Synthetic DNA-encoded monoclonal antibodies make the recipient’s body the production plant.
Despite dramatic progress in cancer therapy, long-term survival is hindered when cancer returns. Tumor cells that escape initial treatment can travel to distant sites in the body and remain hidden…
Dr. Dang, a world-renowned scientist, medical oncologist, National Academy of Medicine member, and professor in Wistar’s Molecular and Cellular Oncogenesis Program, was selected for the 2020…
Predoctoral trainees Sarah Welsh and Joseph Zundell are the recipients of the annual Monica H. M. Shander Memorial Fellowship Award for outstanding predoctoral research.
Pratik Bhojnagarwala is a third-year graduate student in the Cancer Biology Program jointly administered by Wistar and the University of the Sciences. Currently, he’s carrying out thesis work in…
From the many corners of Philadelphia and its surrounding neighborhoods, Wistar colleagues united to run, walk and raise funds supporting our pre- and postdoctoral trainees.