Selected Publications

1. Zhu H, Ren S, Bitler BG, Aird KM, Tu Z, Skordalakes E, Zhu Y, Yan J, Sun Y, Zhang R. SPOP E3 Ubiquitin Ligase Adaptor Epigenetically Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. Cell Reports, 13(6):1183-93, 2015. 

2. Bitler BG, Garipov A, Amatangelo M, Kossenkov A, Schultz  DC, Shih IM, Conejo-Garcia JR, Speicher DW, Zhang R. Targeting EZH2 methyltransferase activity in ARID1A mutated cells is synthetic lethal. Nature Medicine, 21: 231-238, 2015. PMCID: PMC4352133.

3. Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC. PI3K therapy repgrams mitochondrial trafficking to fuel tumor cell invasion. Proc Natl Acad Sci U S A, 112: 8638 -8643, 2015.

4. Bengsch F, Tu Z, Tang HY, Zhu H, Speicher DW, Zhang R. Comprehensive analyis of the ubiquitinome during oncogene-induced senescence in human fibroblasts. Cell Cycle, 14: 1540-1547, 2015.

5. Zhao B, Zhang WD, Lu YQ, Cun YX, Li CH, Guo K, Nie WH, Li L, Zhang R, Zheng P. ESC-specific protein Filia is a master regulator of DNA damage response and safeguards genomic stability of mouse ESCs. Cell Stem Cell, 16: 684-98, 2015.

6. Aird KM, Worth AJ, Snyder NW, Lee JV, Sivanand S, Liu Q, Blair IA, Wellen KE, Zhang R. ATM couples replication stress and metabolic reprogramming during cellular senescence. Cell Reports, 11(6): 893-901, 2015.

7. Yokoyama Y, Zhu H, Zhang R, Noma K. A novel role for the condensin II complex in cellular senescence. Cell Cycle, 14: 2160-2170, 2015.

8. Rutkowski MR, Stephen TL, Svoronos N, Allegrezza MJ, Perales-Puchalt A, Tesone AJ, Escovar-Fadul X, Nguyen JM, Cadungog MG, Zhang R, Salatino M, Rabinovich GA,  Tchou J,  Conejo-Garcia JR. Microbially driven TLR-dependent signalling governs distal malignant progression through tumor-promoting inflammation. Cancer Cell, 27: 27-40, 2015. PMCID: PMC4293269.

9. Zeppernick F, Ardighieri L, Hannibal CG, Vang R, Junge J, Kjaer SK, Zhang R, Kurman RJ, Shih IM.  BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors. American Journal of Surgical Pathology, 38:1603-11, 2014.

10. Aird KM, Li H, Xin F, Konstantinopoulos PA, Zhang R. Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer. Cell Cycle. 13: 199-207, 2014. PMCID: PMC3906237.

11. Mu Z, Li H, Fernandez SV, Alpaugh KR, Zhang R, Cristofanilli M. EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells. J Exp Clin Cancer Res. 32: 70, 2013. PMCID: PMC3850122.

12. Bitler B, Fink L, Wei Z, Peterson JR, Zhang R. A high-content screening assay for small molecule modulators of oncogene-induced senescence. J Biomol Screening. 18: 1054-1061, 2013. PMCID: PMC3870888.

13. Tang HY, Beer LA, Tanyi JL, Zhang R, Liu Q, Speicher DW. Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer. J Proteomics. 89: 165-178, 2013. PMCID: PMC3779132.

14. Amatangelo M, Garipov A, Li H, Conejo-Garcia J, Speicher DW, Zhang R. Three-dimensional culture sensitizes ovarian cancer cells to EZH2 inhibition. Cell Cycle. 12: 2113-2119, 2013. PMCID: PMC3737313.

15. Aird KM, Zhang G, Li H, Tu Z, Bitler BG, Garipov A, Wu H, Wei Z, Wagner SN, Herlyn M, Zhang R. Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Reports. 3: 1252-1265, 2013. PMCID: PMC3840499.

16. Tu Z, Zhuang X, Yao YG, Zhang R. BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss. Mol Cell Biol. 33: 1819-1829, 2013. PMCID: PMC3624184.

17. Garipov A, Li H, Thapa RJ, Balachandran S, Zhang R. NF-YA underlies EZH2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells. Mol Cancer Res. 11: 360-369, 2013. PMCID: PMC3631279.

18. Beer LA, Wang H, Tang HY, Cao Z, Chang-Wong T, Tanyi JL, Zhang R, Liu Q, Speicher, DW. Identification of multiple novel protein biomarkers shed by human serous ovarian tumors into the blood of immunocompromised mice and verified in patient sera. PLoS One. 8: e60129, 2013. PMCID: PMC3609810.

19. Li H, Cai Q, Wu H, Li T, Hua X, Sanchez-Beato M, Zhang R. SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK. Mol Cancer Res. 10: 1462-1472, 2012. PMCID: PMC3501543.

20. Lee S, Rao S, Guitierrez A, Perrigoue J, Thapa R, Tu Z, Rhodes M, Anderson S, Oravecs T, Downing JR, Zhang R, Balachandran S, Zambetti G, Testa JR, Look AT, Wiest D. Mutations in the ribosomal protein L22 promote T lymphoid transformation by induction of the stemness factor, Lin28. Blood. 120: 3764-3773, 2012. PMCID: PMC3488889.

21. Li H, Bitler BG, Maradeo ME, Slifker M, Vathipadiekal V, Careasy C, Tummino P, Cairns P, Birrer MJ, Zhang R. ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches. Cancer Prev Res. 5: 484-491, 2012. PMCID: PMC3294119.

22. Tu Z, Nicodemus J, Beehary N, Xia B, Yen T, Zhang R. Oncogenic Ras regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence. Dev Cell.  21: 1077-1091, 2011. PMCID: PMC3241855.

23. Bitler BG, Nicodemus JP, Li H, Cai Q, Wu H, Hua X, Li T, Birrer MJ, Godwin AK, Cairns P, Zhang R. Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res. 71:6184-6194, 2011. PMCID: PMC3185156.

24. Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, McBryan T, Doyle B, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD. Activation of the PI3K3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell. 42: 36-49, 2011. PMCID: PMC3145340.

25. Li H, Cai Q, Godwin AK, Zhang R. Enhancer of zeste homology 2 promotes the proliferation and invasion of human epithelial cells. Mol Cancer Res. 8: 1610-1618, 2010. PMCID: PMC3059727.

26. Kennedy AL, McBryan T, Enders GH, Johnson FB, Zhang R, Adams PD. Senescent mouse cells fails to overtly regulate the HIRA histone chaperone and do not form robust senescence-associated heterochromatin foci. Cell Div. 5:16, 2010. PMCID: PMC2904742

27. Pleshko A, Einarson MB, Shalginskikh N, Zhang R, Adams PD, Skalka AM, Katz RA. Identification of a functional network of human epigenetic silencing factors. J Biol Chem. 285: 422-433, 2010. PMCID: PMC2804189.

28. Banumathy G, Somaiah N, Zhang R, Schultz D, Andrake M, Ceulemans H, Adams PD.  Human UBN1 is an ortholog of yeast Hpc2 and participates in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Mol Cell Biol. 29: 758-770, 2009. PMCID: PMC2630694.

29. Poleshko A, Palagin I, Zhang R, Boimel P, Castagna C, Adams PD, Skalka AM, Katz RA.  Identification of host factors that maintain retroviral epigenetic silencing: evidence for an antiviral response. J Virol. 82: 2313-2323, 2008. PMCID: PMC2258957.

30. Zhang R, Chen W, Adams PD. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol. 27: 2343-2358, 2007. PMCID: PMC1820509.

31. Ye X, Zerlanko B, Kennedy A, Banumathy G, Zhang R, Adams PD. Downregulation of Wnt signaling is an early signal for formation of facultative heterochromatin and onset of cellular senescence in primary human cells. Mol Cell. 27: 183-196, 2007. PMCID: PMC2698096.

32. Ye X, Zerlanko B, Zhang R, Somaiah N, Lipinski M, Salomoni P, Adams PD. Definition of pRB- and p53- dependent and independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci (SAHF). Mol Cell Biol. 27: 2452-2465, 2007. PMCID: PMC1899904.

33. Zhang R, Liu ST, Chen W, Bonner M, Pehrson JR, Yen TJ, Adams PD. HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol Cell Bio. 27: 949-962, 2007. PMCID: PMC1800672.

34. Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD. Formation of macroH2A-containing senescence-associated heterochromatin foci (SAHF) and senescence driven by ASF1a and HIRA. Dev Cell. 8: 19-30, 2005. PMID: 15621527.