Luis J. Montaner, D.V.M., D.Phil.


The Montaner lab studies the mechanisms of disease in HIV-1 infection and explores new ways to boost the natural function of the immune system in order to combat infection or viral-associated disease. We combine virologic and immune system-based research using laboratory models of virus infection and by working with patients enrolled in clinical trials. Our scientific collaborations extend from Philadelphia to Puerto Rico to San Diego and beyond US borders to Botswana, Canada, Germany, Mexico, and South Africa. These national and global partnerships focus on:

• identifying new mechanisms of immunodeficiency and discovering new approaches to reverse them by enhancing the response of the immune system.

• exploring new ways to manage current HIV-1 therapies, such as studying how to develop immune-mediated control of infection upon interrupting drug therapy.

• understanding the natural ability of our immune system to respond to viruses and comparing that to the immune response of a rare subset of people who are exposed to—yet uninfected by—HIV-1 or are infected yet retain an inherent ability to control their HIV-1 infection.

The Montaner lab has a track record of training scientists from all racial, ethnic, and social backgrounds and genders.  For more information, please refer to the Former Lab Members tab for a list of prior trainees and where they are now.

Dr. Montaner obtained his D.V.M. in Veterinary Medicine from Kansas State University in 1989 and his D. Phil. in Experimental Pathology at the University of Oxford, Oxford, UK in 1995.  He joined The Wistar Institute in 1995 as an assistant professor and was promoted to professor in 2007.  In 2014, Dr. Montaner was honored with the Herbert Kean, M.D. Family Professorship, an endowed chair for his successful program in high-risk, high-reward science. 

He is a sought after national and international lecturer and has published more than 100 manuscripts in highly prestigious peer reviewed journals such as the Proceedings of the National Academy of Sciences, the Journal of Immunology, the Journal of Virology, the Journal of Infectious DiseasesBlood, and the Journal of Biological Chemistry. Dr. Montaner serves as a reviewer for scientific projects for multiple national and international entities, including the National Institutes of Health (USA), ITMAT (France), and AAAS (USA). He is the Editor-in-Chief of the Journal of Leukocyte Biology, a recognized international scientific journal in the field.