David W. Speicher, Ph.D.



Introduction

The Speicher laboratory uses proteomics, metabolomics, computational methods, and biophysical approaches to characterize the roles of normal and mutant proteins in cancers and other human diseases. One approach uses systems biology strategies to better understand tumor progression and resistance to cancer therapeutics as well as to identify clinically useful biomarkers. Other major projects include systematic identification of biomarkers to improve clinical management of cardiotoxicity induced by cancer therapies, identification of ectopic pregnancy biomarkers, and use of chemical crosslinking coupled with high resolution mass spectrometry and molecular modeling to determine structures and dynamics of large protein complexes.