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Gram-Negative - Web Event Banner 2019

Symposium on Gram-Negative Bacterial Resistance

Symposium
Wednesday, Jul. 31, 2019 8:30 a.m. to 6:00 p.m.

The conference focuses on pathophysiology and prevention of gram-negative bacteria. The goal is to bring together leading investigators in the field for in-depth discussions on the current global state of infections that drive antimicrobial resistance (AMR). Perspectives to be covered include strategies to exploit novel bacterial vulnerabilities, updates on cutting-edge approaches towards gram-negative infections and the next steps in combating AMR.

The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104

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Robert A. Bonomo, M.D.

Robert A. Bonomo, M.D.
Case Western Reserve University School of Medicine
Louis Stokes Cleveland Department of Veteran Affairs Medical Center

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Farokh Dotiwala, MBBS, Ph.D.

Farokh Dotiwala, MBBS, Ph.D.
The Wistar Institute

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Thomas J. Hannan, D.V.M., Ph.D.

Thomas J. Hannan, D.V.M., Ph.D.
Washington University School of Medicine
Fimbrion Therapeutics Inc.

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Jonathan Koff, M.D.

Jonathan Koff, M.D.
Yale School of Medicine

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Rahul M. Kohli, M.D., Ph.D.

Rahul M. Kohli, M.D., Ph.D.
University of Pennsylvania, Perelman School of Medicine

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Emily Kramer Golinkoff

Emily Kramer Golinkoff
Emily’s Entourage

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Myron Levine, M.D., DPTH

Myron Levine, M.D., DPTH
University of Maryland School of Medicine

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Paul A. Offit, M.D.

Paul A. Offit, M.D.
Children’s Hospital of Philadelphia

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Ami Patel, Ph.D.

Ami Patel, Ph.D.
The Wistar Institute

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Sanjay Ram, M.D.

Sanjay Ram, M.D.
University of Massachusetts Medical School

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Oren Rosenberg, M.D., Ph.D.

Oren Rosenberg, M.D., Ph.D.
University of California, San Francisco

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Raphael Simon, Ph.D.

Raphael Simon, Ph.D.
Pfizer

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Pranita D. Tamma, M.D.

Pranita D. Tamma, M.D.
Johns Hopkins Medicine

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David B. Weiner, Ph.D.

David B. Weiner, Ph.D.
The Wistar Institute

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Helen I. Zgurskaya, Ph.D.

Helen I. Zgurskaya, Ph.D.
University of Oklahoma

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Daniel V. Zurawski, Ph.D.

Daniel V. Zurawski, Ph.D.
Walter Reed Army Institute of Research

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8:30 - 8:45 AM  

Opening Remarks
David B. Weiner, Ph.D., The Wistar Institute

   

SECTION CHAIR: 
David B. Weiner, Ph.D., The Wistar Institute

8:45 - 9:15 AM  

"Important Gram-negative Publications from the Past Year"
Pranita D. Tamma, M.D.
Johns Hopkins Medicine

9:15 - 9:45 AM  

“Beta-lactamase Inhibitors: A Renaissance”
Robert Bonomo, M.D.
Case Western Reserve University School of Medicine
Louis Stokes Cleveland Department of Veteran Affairs Medical Center

9:45 - 10:15 AM  

"New Strategies for Combating Urinary Tract Infections: Targeting the Mucosal Immune Response and Bacterial Virulence"
Thomas J. Hannan, D.V.M., Ph.D.
Washington University School of Medicine, St. Louis
Fimbrion Therapeutics, Inc.

10:15 - 10:40 AM  

Break

   

SECTION CHAIR: 
Myron M. Levine, M.D., DTPH
University of Maryland School of Medicine 

10:45 - 11:05 AM  

“Neisseria Gonorrhoeae: Targeting Virulence Mechanisms to Develop Novel Immunotherapeutics and Vaccines"
Sanjay Ram, M.D.
University of Massachusetts Medical School

11:05 - 11:25 AM  

“Novel Therapeutic Approaches for Acinetobacter Baumanii Infection"
Daniel Zurawski, Ph.D. 
Walter Reed Army Institute of Research

11:25 - 11:45 AM  

“Disarming the SOS Response to Combat the Evolution of Antibiotic Resistance"
Rahul M. Kohli, M.D., Ph.D.
University of Pennsylvania, Perelman School of Medicine

11:45 - 12:05 PM  

“Reimagining Bacteriophages to Treat Multi-drug Resistant Infections"
Jonathan Koff, M.D.
Yale School of Medicine 

12:05 - 1:00 PM  

Lunch

   

SECTION CHAIR: 
 Daniel Zurawski, Ph.D. 
Walter Reed Army Institute of Research

1:00 - 1:25 PM  

“New Genetic Tools for the Study of Gram-negative Pathogens"
Oren Rosenberg, M.D., Ph.D.
University of California, San Francisco

1:25 - 1:50 PM  

“IspH Inhibitors as Dual Acting Immune Antibiotics"
Farokh Dotiwala, MBBS, Ph.D.
The Wistar Institute 

1:50 - 2:15 PM  

“An Integrative Approach to Multi-drug Efflux and Its Inhibition"
Helen I. Zgurskaya, Ph.D.
University of Oklahoma

2:15 - 2:45 PM  

Break

   

SECTION CHAIR: 
 Helen I. Zgurskaya, Ph.D.
University of Oklahoma

2:50 - 3:10 PM  

“Current and Future Vaccines Against Major Bacterial Enteropathogens (Salmonella, Shigella, Enterotoxigenic Escherichia coli and Vibrio cholerae O1)  that are Increasingly Resistant to Multiple Antibiotics: Lessons Learned."
Myron M. Levine, M.D., DTPH
University of Maryland School of Medicine 

3:10 - 3:30 PM  

"Pseudomonas Immunotherapy: Strategies Using In Vivo DNA Delivery of Monoclonal Antibodies to Control Multi-drug Resistant Pseudomonas Aeruginosa"
Ami Patel, Ph.D.
The Wistar Institute

3:30 - 3:50 PM  

“Carbohydrate Vaccine Approaches for Prevention of Gram-negative Bacterial Infections."
Raphael Simon, Ph.D.
Pfizer Inc.

3:50 - 4:05 PM  

Break

4:05 - 4:15 PM  

Patient Perspective
Emily Kramer-Golinkoff, Emily’s Entourage

4:15 - 5:00 PM  

Panel Discussion
Moderator: Paul A. Offit, M.D., Children’s Hospital of Philadelphia
Denis Hadjiliadis, M.D., MHS, Ph.D., University of Pennsylvania,
Perelman School of Medicine

Kathrin U. Jansen, Ph.D., Pfizer Inc.
Jonathan Koff, M.D., Yale School of Medicine
Sanjay Ram, M.D., University of Massachusetts Medical School

5:00 - 6:00 PM  

Closing Remarks
Farokh Dotiwala, MBBS, Ph.D., The Wistar Institute
Reception to follow in the Atrium