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The Noreen O'Neill Melanoma Research Symposium: Host Response in Melanoma

Symposium
Tuesday, Jun. 26, 2018 9:00 a.m. to 4:30 p.m.

The past decade has seen tremendous advances in the treatment of melanoma with next generation approaches like targeted therapies, immunotherapies and combination therapies that have changed the disease outcome for many patients. Despite the success of these varied strategies, the onset of drug resistance, or failure to respond to therapies at all remains a problem for the majority of patients. How the host and tumor microenvironment play a role in the success of failure of these therapies is an important area of study.

The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104

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Speakers

 
Donita C. Brady, Ph.D.
University of Pennsylvania
 
Timothy Chan, M.D., Ph.D.
Memorial Sloan Kettering Cancer Center
 
Patrick Hwu, M.D.
MD Anderson Cancer Center
 
Carmit Levy, Ph.D.
Tel Aviv University
 
Richard Marais, Ph.D.
Cancer Research UK Manchester Institute
 
Sergio Quezada, Ph.D.
University College London
 
Suzanne Topalian, M.D.
Johns Hopkins University School of Medicine
 
Thomas Tüting, M.D.
Otto-von-Guericke Universität Magdeburg
 
Jennifer Wargo, M.D.
MD Anderson Cancer Center
 
Ashani T. Weeraratna, Ph.D.
The Wistar Institute

Agenda

This is a preliminary agenda. Please check back for updates closer to the symposium.

8:00 AM  

Registration and Breakfast
9:00 AM  

Welcome
Jessie Villanueva, Ph.D.
Assistant Professor, Molecular and Cellular Oncogenesis Program
Member, The Wistar Institute Melanoma Research Center
The Wistar Institute
9:15 - 9:45 AM  

“The Microbiome and Response to Melanoma Therapy”
Jennifer Wargo, M.D.
Associate Professor, Surgical Oncology and Genomic Medicine Departments
MD Anderson Cancer Center
9:45 - 10:15 AM  

“Immunotherapy: Evolving Landscape of Mechanisms and Biomarkers”
Timothy Chan, M.D., Ph.D.
Vice Chair, Department of Radiation Oncology
Director, Division of Translational Oncology
Memorial Sloan Kettering Cancer Center
10:15 - 10:30 AM  

Break
10:30 - 11:00 AM  

“UV Exposure, Adipocytes and Melanoma”
Carmit Levy, Ph.D.
Senior Lecturer, Department of Human and Molecular Genetics and Biochemistry
Tel Aviv University
11:00 - 11:30 AM  

“New Insights into Copper-Modulated MAPK Signaling Essential for BRAFV600E Tumorigenesis”
Donita C. Brady, Ph.D.
Presidential Assistant Professor, Department of Cancer Biology
University of Pennsylvania
11:30 AM - 12:00 PM  

“A Wrinkle in TiME- How the Aging TME Drives Melanoma Progression”
Ashani T. Weeraratna, Ph.D.
Ira Brind Professor
Professor and Co-Program Leader, Immunology, Microenvironment and Metastasis Program
Member, The Wistar Institute Melanoma Research Center
The Wistar Institute
12:00 PM  

Lunch
1:15 - 1:45 PM  

“From Basic Biology to Therapeutic Opportunities in Melanoma”
Richard Marais, Ph.D.
Professor of Molecular Oncology
Director, Cancer Research UK Manchester Institute
Cancer Research UK Manchester Institute
1:45 - 2:15 PM  

“Adaptive Plasticity of Tumor and Immune Cells in the Melanoma Microenvironment”
Thomas Tüting, M.D.
Professor and Chairman, Dermatology
Otto-von-Guericke Universität Magdeburg
2:15 - 2:30 PM  

Break
2:30 - 3:00 PM  

“Intrinsic Tumor Genomic and Metabolic Factors Leading to Immunoresistance”
Patrick Hwu, M.D.
Head, Division of Cancer Medicine
MD Anderson Cancer Center
3:00 - 3:30 PM  

“PD-1 Blockade in Melanoma and Other Skin Cancers”
Suzanne Topalian, M.D.
Professor, Surgery and Oncology
Director, Melanoma Program
Associate Director, Johns Hopkins Bloomberg-Kimmel Institute for Cancer Immunotherapy
Johns Hopkins University School of Medicine
3:30 - 4:00 PM  

“Targeting Regulatory T cells for Therapeutic Gain: Means and Mechanisms”
Sergio Quezada, Ph.D.
Group Leader, Immune Regulation and Tumor Immunotherapy Lab
University College London
4:00 - 4:15 PM  

Closing Remarks
Meenhard Herlyn, D.V.M., D.Sc.
Director, The Wistar Institute Melanoma Research Center
Professor, Molecular and Cellular Oncogenesis Program
The Wistar Institute
4:30 - 6:00 PM  

Reception and Poster Session