Epigenetics in Cancer 2019

Symposium

Thursday, Apr. 25, 2019 9:30 a.m. to 5:30 p.m.

The study of epigenetics and chromosome dynamics has reshaped our understanding of tumor biology for over a decade. This second “Epigenetics in Cancer” symposium will bring together leaders in basic and translational research to promote a better understanding of epigenetic pathways as drug targets in cancer therapy.

The symposium is organized by The Wistar Institute’s Gene Expression and Regulation Program.

The Wistar Institute
3601 Spruce Street
Philadelphia, PA, 19104

Keynote Speakers

Shelley L. Berger, Ph.D.
Daniel S. Och University Professor; Director, Epigenetic Institute
Perelman School of Medicine University of Pennsylvania

Kristian Helin, Ph.D.
Chair, Cell Biology Program; Director, Center for Epigenetics
Memorial Sloan Kettering Cancer Center

Speakers

Ben E. Black, Ph.D.
Professor of Biochemistry and Biophysics
Perelman School of Medicine at the University of Pennsylvania

Alessandro Gardini, Ph.D.
Assistant Professor
The Wistar Institute

Ari M. Melnick, M.D.
Gebroe Family Professor of Hematology/Oncology; Director, Sackler Center for Biomedical and Physical Sciences
Weill Cornell Medical College

Kazuko Nishikura, Ph.D.
Professor
The Wistar Institute

Agnel Sfeir, Ph.D.
Associate Professor of Cell Biology
New York University

Emmanuel Skordalakes, Ph.D.
Associate Professor
The Wistar Institute

Martin Walsh, Ph.D.
Professor of Pharmacological Sciences; Director, The Mount Sinai Center for RNA Biology and Medicine
Mount Sinai School of Medicine

Johnathan Whetstine, Ph.D.
Professor and Program Leader, Cancer Epigenetics Program
Fox Chase Cancer Center

Thank you to our sponsors:

Also supported by Cayman Chemical Company.

Agenda

9:30 AM		Welcome & Opening Remarks Paul Lieberman, Ph.D. Professor and Program Leader, Gene Expression and Regulation Program Director, Center for Chemical Biology and Translational Medicine Hilary Koprowski, M.D., Endowed Professor The Wistar Institute
9:40 AM		Session #1 From Chromosome Maintenance to Epigenetics Moderator: Paul Lieberman, Ph.D.
9:45 AM		“How Centromeric Chromatin Organizes the Chromosome/Kinetochore Interface” Ben E. Black, Ph.D. Professor of Biochemistry and Biophysics Perelman School of Medicine, University of Pennsylvania
10:15 AM		“Telomeric POT1-TPP1 and Cancer” Emmanuel Skordalakes, Ph.D. Associate Professor, Gene Expression and Regulation Program The Wistar Institute
10:45 AM		“Single-molecule Analysis of Telomerase RNA in Cancer Cells” Agnel Sfeir, Ph.D. Associate Professor, Department of Cell Biology Skirball Institute of Biomolecular Medicine NYU Langone Medical Center
11:15 AM		Break
11:30 AM		“Epigenetics: A Gatekeeper to DNA Amplification and Drug Response” Johnathan Whetstine, Ph.D. Professor and Program Leader, Cancer Epigenetics Program Fox Chase Cancer Center
12:00 PM		“Chromatin Architecture, Epigenetic Regulators and Lymphomagenesis” Ari M. Melnick, M.D. Gebroe Family Professor of Hematology/Oncology Director, Sackler Center for Biomedical and Physical Sciences Weill Cornell Medical College
12:30 PM		Lunch Break
1:30 PM		Sponsor Presentation: “GenScript Discovery and Biologics CDMO Services” Sasidhar Murikinati, Ph.D. Product Manager for Biologics Discovery and Development Services GenScript
2:00 PM		Session #2 Epigenetic Control of Transcription in Cancer Moderator: Rugang Zhang, Ph.D. Deputy Director, The Wistar Institute Cancer Center Professor and Program Co-leader, Gene Expression and Regulation Program The Wistar Institute
2:10 PM		Keynote Presentation: “p53 and p63 Epigenetic Pathways in Cancer and Development” Shelley L. Berger, Ph.D. Daniel S. Och University Professor Director, Epigenetics Institute Perelman School of Medicine, University of Pennsylvania
2:55 PM		“Linking Transcription and Epigenetics with Integrator” Alessandro Gardini, Ph.D. Assistant Professor, Gene Expression and Regulation Program The Wistar Institute
3:25 PM		“Regulation of Genome Stability by ADAR RNA Editing Enzymes” Kazuko Nishikura, Ph.D. Professor, Gene Expression and Regulation Program The Wistar Institute
3:55 PM		Break
4:10 PM		“Mapping Tumor Cell Enhancer Fate by Single-cell ATAC and a Novel CRISPR Interference Screen” Martin J. Walsh, Ph.D. Professor, Pediatrics, Pharmacological Sciences, and Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai
4:40 PM		Keynote Presentation: “Role of the Polycomb Repressive Complex 2 in Transcription and Cancer” Kristian Helin, Ph.D. Chair, Cell Biology Program Director, Center for Epigenetics Memorial Sloan-Kettering Cancer Center
5:25 PM		Closing Remarks Rugang Zhang, Ph.D.
5:30 PM		Reception

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Keynote Speakers

Speakers

Thank you to our sponsors:

Agenda