The TP53 gene is the most frequently mutated gene in human cancer. In addition to mutations, this gene comes in numerous variations in the human population. Some of these variations alter the function of the p53 protein. A collaborative study fro…
Nikon Small World opening night brought to Wistar a crowd of science and art enthusiasts to marvel at the beautiful images of 2019 and listen to first-place winners talk about the work behind their winning image — made up of more than one thousand…
PHILADELPHIA — (Jan. 30, 2020) — Combining EZH2 inhibition and PARP1 inhibition may provide a new therapeutic strategy for ovarian cancers that have functional DNA damage repair and thus would not typically respond to PARP inhibitor treatment alon…
PHILADELPHIA — (Jan. 24, 2020) — In a study by The Wistar Institute and collaborators, a rare, African-specific variant of the TP53 gene called P47S causes iron accumulation in macrophages and other cell types and is associated with poorer respons…
PHILADELPHIA — (Jan. 23, 2020) — The Wistar Institute announces today that they are part of a team to develop a vaccine against the recently emerged strain of coronavirus (2019-nCoV) that has infected hundreds in China and other countries, includi…
PHILADELPHIA — (Jan. 11, 2020) — Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute publi…
PHILADELPHIA — (Dec. 19, 2019) — In the past six months, scientists at The Wistar Institute received funding from private foundations totaling $2,418,000 that will fuel new discoveries in cancer, immunology and infectious diseases. ### The Wistar …
PHILADELPHIA — (Dec. 19, 2019) — A study from The Wistar Institute demonstrated that NAMPT, an enzyme critical for NAD+ biosynthesis, mediates selection of stem-like chemoresistant cells following cisplatin treatment. Researchers showed that a com…
PHILADELPHIA — (Dec. 17, 2019) — See cellular images as distinct as abstract art, minerals appear as future urban landscapes, single-celled organisms of the microscopic netherworld, and much more from the 2019 Nikon Small World competition of phot…
Keerthana Gnanapradeepan, a trainee in the Murphy lab, is the recipient of the 2019 Monica H.M. Shander Memorial Fellowship Award. This prestigious award was established in 1981 in memory of former Wistar predoctoral trainee Monica&…
