HomeTechnology TransferTechnologiesSmall Molecule Inhibitors of MicroRNA miR21
Technology Transfer

Small Molecule Inhibitors of MicroRNA miR21

Inventor(s)
Tech ID
HQ08001
Key Words
Cancer, cancer treatment, hear failure, micro-RNA, miR-21, oncology, small molecule therapeutic
Applications and Advantages

This technology is useful for developing first-in-class selective microRNA inhibitors for treatment of cancer and heart failure. The small molecule miR-21 inhibitors that have been developed using the technology may be candidates for treatment of these diseases, either alone or in combination with known drugs.

Intellectual Property Status

PCT Application No. PCT/US2009/034611, filed 02/20/2009.

Licensing Opportunity

Wistar is seeking corporate partners to collaborate in (i) the validation and development of the miR21 inhibitors compounds, and (ii) the identification of new microRNA inhibitors using our novel assay system. An exclusive license or sponsored research agreement would be considered.

Relevant Publication(s)

Gumireddy, K., Young, D. D., Xiong, D., Hogenesch, J. B., Huang, Q., Deiters, A. (2008) “Small Molecule Inhibitors of MicroRNA miR-21 Function”. Angewandte Chemie International Edition 47(39):7482-7484.