By Inventor

  • Monoclonal Antibodies For Influenza Research  

    Characteristics: These antibodies specifically bind to the identified antigens on influenza viruses. All of the antibodies are useful for ELISA and some of the antibodies are also useful for Western blot. The specificity of the various antibodies that have been characterized is as shown:

    Antibody

    Isotype

    Specificity

    Reference

     

    H36-4-5.2

    IgG2a/k

    H1 (PR8)

    2, 3, 5, 7-8, 11

     

    NA-112-S2.4

    IgG2a/k

    N1 (PR8)

    9

     

    H15-B9-22

    IgG2a/k

    H1 (WSN)

    6

     

    CM1-4

    IgG2b/k

    H1 (110-120)

     
       

    Reacts with 1934-1957 strains

     
       

    Later strains nd

     
     

    H14-A21-1R1

    G1/k

    H3 (Aichi/68, Mem/72, others nd)

    4

     

    M1-1C6-5

    G1/k

    M1

    1

    H18-S12-3

    G2a/k

    M1

    1

     

    M2-56

    G2a/k

    M2

    10

     

    H16-L10-4R5

    G2a/k

    NP (x-reacts with PR8 and Aichi)

    1

    H19-S24-4

    G2a/k

    NP (x-reacts with early H1N1 strains)

    1

     

    1.1B8

    G2a/k

    H (B/Lee)

     

    References:

    1. Yewdell, J.W., Frank, E., and Gerhard, W. J. Immunol. 126: 1814-1819, 1981.

    2. Gerhard, W., Yewdell, J., Frankel, M., and Webster, R.G. Nature 290: 713-717, 1981.

    3. Caton, A.J., Brownlee, G.G., Yewdell, J.W., and Gerhard, W. Cell 31: 417-427, 1982.

    4. Jackson, D.C., Murray, J.M., White, D.O., and Gerhard, W. Infec. and Immunity 37: 912-918, 1982.

    5. Staudt, L.M. and Gerhard, W. J. Exp. Med. 157: 687-704, 1983.

    6. Nohinek et al. Virology 143: 651-656, 1985.

    7. Kavaler J et al. J. Immunol. 145: 2312-2321, 1990.

    8. Caton, A.J., Stark, S.E., Kavaler, J., Staudt, L.M., Schwartz, D., and Gerhard, W. J. Immunol. 147: 1675-1687, 1991.

    9. Mozdzanowska et al. Virology 254: 138-146, 1999.

    10. Zhang, M., Zharikova, D., Mozdzanowska, K., Otvos, L., and Gerhard, W. Mol. Immunol. 43: 2195-2206, 2006.

    11. Mozdzanowska, K., Feng, J., Eld, M., Zharikova, D., Gerhard, W. Virology (in press), 2006.