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Seasonal influenza viruses pose a major threat to the human population, contributing to over 30,000 annual deaths in the United States alone. Influenza viruses rapidly escape pre-existing humoral immunity by accumulating mutations in the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). This process, termed “antigenic drift”, creates antigenically distinct viruses, making it difficult to predict which types of viruses will predominate during any given flu season. Antigenic drift is a huge problem for vaccine manufacturers.
The Hensley laboratory has two major scientific focuses: 1) elucidating mechanisms that promote antigenic drift of influenza viruses; and 2) identifying factors that influence influenza vaccine responsiveness. Our overarching goals are to use basic immunological and virological approaches to improve the process by which influenza vaccine strains are chosen and to develop new influenza vaccines that are protective against antigenically diverse influenza strains.
It is an exciting time to study influenza viruses, and enthusiastic, highly motivated undergraduate, graduate, and postdoctoral fellows should email email@example.com if you are interested in joining the lab.
The microscope in the image belonged to William E. Horner, M.D., a collaborator with Caspar Wistar, M.D., in the early 1800s.
Dr. Horner, a lecturer at the University of Pennsylvania, was a pioneer of the use of microscopes in anatomical and medical research. He authored Special Anatomy and Histology, a seminal text on the subject.