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The Wistar Institute

3601 Spruce Street

Room 308

Philadelphia, PA 19104

Office: 215-495-6840

rzhang@wistar.org

Selected Publications

1 - Aird KM, Zhang G, Li H, Tu Z, Bitler BG, Garipov A, Wu H, Wei Z, Wagner SN, Herlyn M, Zhang R. Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Reports, in press, 2013.

2 - Tu Z, Zhuang X, Yao Y, Zhang R. BRG1 is required for formation of senescence-associated heterochromatin foci (SAHF) induced by oncogenic RAS or BRCA1 loss. Mol Cell Biol, in press, 2013. PMID: 23438604

3 - Li H, Zhang R. Role of EZH2 in epithelial ovarian cancer: from biological insights to therapeutic target. Frontiers in Oncology, in press, 2013.

4 - Garipov A, Li H, Bitler BG, Thapa RJ, Balachandran S, Zhang R. NF-YA underlies EZH2 upregulation and is essential for proliferation of human epithelial ovarian cancer cells. Mol Cancer Res. Published online first January 29, 2013; doi:10.1158/1541-7786.MCR-12-0661 PMID: 23360797

5 - Aird KM, Zhang R. Detection of Senescence-Associated Heterochromatin Foci (SAHF). Methods Mol Biol. 2013;965:185-96. doi: 10.1007/978-1-62703-239-1_12. PMID: 23296659

6 - Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson, S., Oravecz, T., Hunger, S.P., Timakhov, R.A., Zhang, R., Balachandran, S., Zambetti, G.P., Testa, J.R., Look, A.T. and Wiest, D.L. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood. 120: 3764-73, 2012. PMC3488889 PMID: 22976955

7 - Tu Z, Aird KM, Zhang R. RAS, cellular senescence and transformation: the BRCA1 DNA repair pathway at the crossroads. Small GTPases. 3: 163-167, 2012. PMC3442802 PMID: 22751483

8 - Li H, Cai Q, Wu H, Vathipadiekal V, Dobbin ZC, Li T, Hua X, Landen CN, Birrer MJ, Sánchez-Beato M, Zhang R. SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK. Mol Cancer Res. 2012 Nov;10(11):1462-72. Epub 2012 Sep 10. PMID: 22964433

9 - Li H, Bitler BG, Vathipadiekal V, Maradeo ME, Slifker M, Creasy CL, Tummino PJ, Cairns P, Birrer MJ, Zhang R. ALDH1A1 Is a Novel EZH2 Target Gene in Epithelial Ovarian Cancer Identified by Genome-Wide Approaches. Cancer Prev Res (Phila). 2012 Mar;5(3):484-91. Epub 2011 Dec 5. PMID: 22144423

10 - Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, Xia B, Yen TJ, Zhang R. Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence. Dev Cell. 2011 Dec 13;21(6):1077-91. Epub 2011 Dec 1. PMID: 22137763

11 - Bitler BG, Nicodemus JP, Li H, Cai Q, Wu H, Hua X, Li T, Birrer MJ, Godwin AK, Cairns P, Zhang R. Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res. 2011 Oct 1;71(19):6184-94. Epub 2011 Aug 4. PMID: 21816908

12 - Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, McBryan T, Doyle B, McKay C, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD. Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell. 2011 Apr 8;42(1):36-49. PMID: 21474066

13 - Li H, Cai Q, Godwin AK, Zhang R. Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells. Mol Cancer Res. 2010 Dec;8(12):1610-8. Epub 2010 Nov 29. PMID: 21115743

14 - Poleshko A, Einarson MB, Shalginskikh N, Zhang R, Adams PD, Skalka AM, Katz RA. Identification of a functional network of human epigenetic silencing factors. J Biol Chem. 2010 Jan 1;285(1):422-33. Epub 2009 Oct 30. PMID: 19880521

15 - Ye X, Zerlanko B, Kennedy A, Banumathy G, Zhang R, Adams PD. Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell. 2007 Jul 20;27(2):183-96. PMID: 17643369

16 - Zhang R, Chen W, Adams PD. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol. 2007 Mar;27(6):2343-58. Epub 2007 Jan 22. PMID: 17242207

17 - Zhang R, Liu ST, Chen W, Bonner M, Pehrson J, Yen TJ, Adams PD. HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. Mol Cell Biol. 2007 Feb;27(3):949-62. Epub 2006 Nov 13. PMID: 17101789

18 - Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell. 2005 Jan;8(1):19-30. PMID: 15621527