Research in our lab focuses on developing informatics solutions to solve problems in biology and medicine. Current projects are focused on two closely related areas – (A) mammalian gene regulation at isoform-level, and (B) isoform-level gene regulatory networks in brain development and brain tumors. The overarching goal of our lab is to translate data from high dimensional (-omic) platforms (e.g., NextGen sequencing) to derive experimentally interpretable and testable discovery models towards genomics-based clinical decision support systems for personalized cancer therapy. Towards these goals, our group applies state-of-the-art statistically rigorous data-mining methods and NextGen sequencing based experimental procedures in a systems biology setting.
Our research program is interdisciplinary in nature with a complement of experimental investigation. The current projects of the laboratory are:
- Bioinformatics platform for mammalian gene regulation at isoform-level
- Isoform-level gene regulatory networks in brain development and brain tumors
- Decision support systems for molecular classification of cancers