The Lieberman laboratory focuses on fundamental mechanisms of genome maintenance. Both viral and cellular genomes share common features that are required to maintain and propagate their genomes. For viral genomes, like Epstein-Barr Virus (EBV) and Kaposi’s Sarcoma-Associated Herpesvirus (KSHV), persistence as a viral minichromosome in the host-cell nucleus correlates with increase risk of pathology, including carcinogenesis. For the human genome, loss of structural maintenance leads to genetic instability and cancer cell evolution. Remarkably, several mechanisms of genome maintenance are shared by both viral and host genomes. The laboratory focuses on the key mechanisms that preserve genome integrity, and is developing methods for therapeutic intervention using chemical biology and small molecule drug design.