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The laboratory has a long history of collaborations with members of the Penn/Wistar campus, particularly those who have had an interest in melanoma (Table 1). The Program Project on Etiology, Progression and Therapy has been continuously funded since 1980. This Program Project fosters interactions with outside investigators, and coordinates the many related activities that define a Melanoma Research Center. Since 2008, the Program Project on Targeted therapies in melanoma has exemplified the multidisciplinary nature of our research, as the four projects are represented by biologists, immunologists, structural biologists, chemists, pathologists, oncologists and biostatisticians. These programs have supported several critically important resources: 1) development of more than 400 cell lines from melanocytic lesions of different stages of progression; 2) MAbs against melanoma-associated antigens; 3) Biological models of human melanoma; and 4) Viral vectors for either up regulation of gene expression or knock-down. Figure 1 iillustratates how these grants operate independenty yet all depend on shared expertise in the Cores.
Table 1: Collaborations at Wistar and the University of Pennsylvania
Figure 1: Grant Collaborations
The microscope in the image belonged to William E. Horner, M.D., a collaborator with Caspar Wistar, M.D., in the early 1800s.
Dr. Horner, a lecturer at the University of Pennsylvania, was a pioneer of the use of microscopes in anatomical and medical research. He authored Special Anatomy and Histology, a seminal text on the subject.