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The Wistar Institute

3601 Spruce Street

Room 352

Philadelphia, PA 19104

 

Office: 215-495-6870
Lab: 215-898-0654

Publications

1 - Balaburski GM, Leu JI, Beeharry N, Hayik S, Andrake MD, Zhang G, Herlyn M, Villanueva J, Dunbrack RL Jr, Yen T, George DL, Murphy ME. A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res. 2013 Jan 9. [Epub ahead of print] PubMed PMID: 23303345.

2 - Balaburski GM, Budina A, and Murphy ME. Oncogenes and tumor suppressor genes in autophagy.  In: Autophagy and Cancer.  HG Wang, ed.  Springer Publishing, 2013.

3 - Pimkina JS and Murphy ME. Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function.  Cancer Biol Ther,  2011, 12:503-9.

4 - Leu JI, Pimkina J, Pandey P, Murphy ME, George DL. The Heat Shock Protein-70 (HSP70) Inhibitor 2-phenylethynesulfonamide (PES) Disrupts Protein Degradation Pathways and the HSP70/HSP90 Chaperone System in Tumor Cells.  Mol Cancer Res, 2011, 9:936-47.

5 - Azzam GA, Frank AK, Hollstein M, Murphy ME. Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model. Cell Cycle, 2011 May 1;10(9):1352-5.

6 - Feng Z, Zhang C, Kang HJ, Sun Y, Wang H, Naqvi A, Frank AK, Rosenwaks Z, Murphy ME, Levine AJ, Hu W. Regulation of female reproduction by p53 and its family members. FASEB J. 2011 Mar 14. [Epub ahead of print] PubMed PMID: 21402718.

7 - Frank AK, Pietsch EC, Dumont P, Tao J, Murphy ME. Wild-type and mutant p53 proteins interact with mitochondrial caspase-3. Cancer Biol Ther. 2011 Apr 15;11(8):740-5. Epub 2011 Apr 15. PubMed PMID: 21307660; PubMed Central PMCID: PMC3100564.

8 - Frank, AK, Leu JI, Zhou Y, Devarajan K, Nedelko T, Klein-Szanto A, Hollstein M, Murphy ME. The codon 72 polymorphism of p53 regulates interation with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Mol Cell Biol. 2011 Mar;31(6):1201-13. Epub 2011 Jan 18. PubMed PMID: 21245379; PubMed Central PMCID: PMC3067895.

9 - Balaburski G, Hontz R and Murphy ME. p53 and ARF: Unexpected players in autophagy. Trends in Cell Biology, 2010 Jun;20(6):363-9.

10 - Whibley C, Odell AF, Nedelko T, Balaburski G, Murphy M, Liu Z, Stevens L, Walker JH, Routledge M, Hollstein M. Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence. J Biol Chem. 2010 Apr 9;285(15):11326-35.

11 - Leu JI, Pimkina J, Frank A, Murphy ME, and George DL. A Small Molecule Inhibitor of Inducible Heat Shock Protein 70 (HSP70). Mol Cell 36:15-27, 2009.

12 - Sykes SM, Stanek TJ, Frank A, Murphy ME, McMahon SB. Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem. 284:20197-205, 2009.

13 - Kang HJ, Feng Z, Sun Y, Atwal G, Murphy ME, Rebbeck TR, Rosenwaks Z, Levine AJ, Hu W. Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9761-6.

14 - Pimkina J, Humbey O, Zilfou JT, Jarnik M, Murphy ME. ARF Induces Autophagy by Virtue of Interaction with Bcl-xl. J Biol Chem. 2009 Jan;284(5):2803-10.

15 - Pimkina J, Murphy ME. ARF, autophagy and tumor suppression. Autophagy. 2009 Apr;5(3):397-9.

16 - Humbey O, Pimkina J, Zilfou JT, Jarnik M, Dominguez-Brauer C, Burgess DJ, Eischen CM, Murphy ME. The ARF Tumor Suppressor Can Promote the Progression of Some Tumors. Cancer Res. 2008 Dec 1;68(23):9608-13.

17 - Pietsch EC, Murphy ME. Low risk HPV-E6 traps p53 in the cytoplasm and induces p53-dependent apoptosis. Cancer Biology & Therapy. 2008 Dec;7(12):1916-8.

18 - Pietsch EC, Perchiniak E, Canutescu AA, Wang G, Dunbrack RL, Murphy ME. Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain. J Biol Chem. 2008 Jul 25;283(30):21294-304.

19 - Pietsch EC, Sykes SM, McMahon SB, Murphy ME. The p53 family and programmed cell death. Oncogene. 2008 Nov 13;27(50):6507-21.

20 - Reinbold M, Luo JL, Nedelko T, Jerchow B, Murphy ME, Whibley C, Wei Q, Hollstein M. Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72. Oncogene. 2008 Apr;27(19):2788-94.

21 - Mellert H, Sykes SM, Murphy ME, McMahon SB. The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle. 2007 Jun;6(11):1304-6.

22 - Pietsch EC, Leu JI, Frank A, Dumont P, George DL, Murphy ME. The tetramerization domain of p53 is required for efficient BAK oligomerization. Cancer Biology & Therapy. 2007 Oct;6(10):1576-83.

23 - Murphy ME. Polymorphic variants in the p53 pathway. Cell Death Differ. 2006 Jun;13(6):916-20.

24 - Pietsch EC, Humbey O, Murphy ME. Polymorphisms in the p53 pathway. Oncogene. 2006 Mar;25(11):1602-11.

25 - Tang BQ, Kadariya Y, Murphy ME, Kruger WD. The methionine salvage pathway compound 4-methylthio-2oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase. Biochem Pharmacol. 2006 Sep;72(7):806-15.

26 - Li X, Dumont P, Della Pietra A, Shetler G, Murphy ME. The codon 47 polymorphism in p53 is functionally significant. J Biol Chem. 2005;280(25):24245-51.

27 - Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, Xu Y. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol. 2005 Feb;7(2):165-71.

28 - Leu JI, Dumont P, Hafey M, Murphy ME, George DL. Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nature Cell Biology. 2004 May;6(5):443-50.

29 - Murphy ME, Leu JI, George DL. p53 moves to mitochondria - A turn on the path to apoptosis. Cell Cycle. 2004 Jul;3(7):836-9.

30 - Razak ZR, Varkonyi RJ, Kulp-McEliece M, Caslini C, Testa JR, Murphy ME, Broccoli D. p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance. Mol Cell Biol. 2004 Jul;24(13):5967-77.

31 - Sax JK, Stoddard A, Murphy ME, Chodosh L, El-Deiry WS. Microarray expression profiling of p53-dependent transcriptional changes in an immortalized mouse embryo fibroblast cell line. Cancer Biol Ther. 2003 Jul-Aug;2(4):416-30.

32 - Dumont P, Della Pietra A, Murphy ME. Methods to study p53-repressed promoters. Methods in Molecular Biology (Totowa, NJ, United States). 2003;234(p53 Protocols):111-20.

33 - Dumont P, Leu JI, Della Pietra AC, George DL, Murphy M. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet. 2003 Mar;33(3):357-65.

34 - Bao R, Connolly DC, Murphy M, Green J, Weinstein JK, Pisarcik DA, Hamilton TC. Activation of cancer-specific gene expression by the survivin promoter. J Natl Cancer Inst. 2002 Apr 3;94(7):522-8.