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The Wistar Institute

3601 Spruce Street

Philadelphia, PA 19104

Introduction

RNA carries the genetic instructions of DNA to the cellular machinery responsible for synthesizing the proteins of the body. The Nishikura laboratory is exploring the phenomenon of RNA editing, a process by which a single gene can produce a number of RNA variants and consequently closely related but distinct proteins. Recent studies suggest that disruptions in RNA editing may play a role in control of programmed cell death as well as depression and metabolic diseases.