The laboratory of Hildegund C.J. Ertl, M.D., focuses on pre-clinical development of vaccines to infectious diseases and cancer, emphasizing basic immunological mechanisms that influence vaccine efficacy. Specifically, the laboratory explores viral recombinant vaccines based on chimpanzee-derived adenoviral vectors. Major ongoing projects include a preventive vaccine to rabies virus, a therapeutic cancer vaccine targeting human papillomavirus which is associated with cervical cancer, vaccines to prevent human immunodeficiency virus (HIV) infection, and a universal vaccine against influenza A virus.
The team is composed of senior scientists, technicians, post- and pre-doctoral fellows, part-time undergraduate students and intern high school students.