Introduction
The Puré laboratory is investigating the molecular and cellular mechanisms underlying inflammation and fibrosis, which play a significant role in a wide array of diseases, including atherosclerosis, asthma, rheumatoid arthritis, liver cirrhosis, scleroderma, pulmonary fibrosis, and cancer. Cellular responses and molecular pathways mediated by the adhesion receptor CD44, the cell surface protease FAP, and 12/15-lipoxygenase, an enzyme involved in fatty acid metabolism, are being studied. These investigations may reveal promising targets for new drug therapies for application in inflammatory and fibrotic diseases.
