Introduction
The Speicher laboratory uses proteomics, computational methods, and biophysical approaches to characterize the roles of normal and mutant proteins in cancers and other human diseases. One approach uses systems biology strategies to better understand tumor progression and resistance to cancer therapeutics. Other major projects include systematic identification of biomarkers to improve clinical management of cancer, identification of ectopic pregnancy biomarkers, defining the role of innate immunity and resistance to HIV infection, structural analysis of the red cell membrane skeleton, and mechanisms for protecting membranes from oxidative stress.
