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The Wistar Institute

3601 Spruce Street

Philadelphia, PA 19104

 

Office: 215-495-6975

Introduction

The Altieri laboratory studies the cellular and molecular mechanisms of tumor adaptation.  This is a dynamic process that enables tumor cells to constantly adjust to unfavorable and potentially noxious environments and maintain their proliferative capacity, ability to survive, and establish metastatic foci in distant organs.  Although these processes are complex and likely multifactorial, tumor cell adaptation depends on the interplay between cell survival, metabolism, and proliferation.  The Altieri laboratory studies gene networks implicated in these processes, specifically, the Inhibitors of Apoptosis (IAP) gene family, molecular chaperones of the Heat Shock Protein 90 (Hsp90) family and the properties of mitochondrial bioenergetics related to tumor cell metabolism.