JOIN US IN SAVING LIVES
Please make a 2013 year-end donation and help us cure cancer and other deadly diseases.Donate >
The Altieri laboratory studies the cellular and molecular mechanisms of tumor adaptation. This is a dynamic process that enables tumor cells to constantly adjust to unfavorable and potentially noxious environments and maintain their proliferative capacity, ability to survive, and establish metastatic foci in distant organs. Although these processes are complex and likely multifactorial, tumor cell adaptation depends on the interplay between cell survival, metabolism, and proliferation. The Altieri laboratory studies gene networks implicated in these processes, specifically, the Inhibitors of Apoptosis (IAP) gene family, molecular chaperones of the Heat Shock Protein 90 (Hsp90) family and the properties of mitochondrial bioenergetics related to tumor cell metabolism.
The microscope in the image belonged to William E. Horner, M.D., a collaborator with Caspar Wistar, M.D., in the early 1800s.
Dr. Horner, a lecturer at the University of Pennsylvania, was a pioneer of the use of microscopes in anatomical and medical research. He authored Special Anatomy and Histology, a seminal text on the subject.