Robert A. Weinberg, Ph.D., of Whitehead Institute for Biomedical Research will present this lecture at 10:00 a.m. in the Grossman Auditorium. 

Free and open to the public. For more information, call 215-898-3944.

Carcinoma cells undergo a profound phenotypic shift within primary tumors termed the epithelial-mesenchymal transition (EMT), which imparts to them many of the attributes of mesenchymal cells, including motility, invasiveness and a heightened resistance to apoptosis.  This empowers cancer cells to disseminate from primary tumors and, at the same time, to serve as founders of distant metastatic colonies.  This program appears to be triggered by contextual signals that carcinoma cells receive from the nearby stromal microenvironment that is generated as primary tumors develop. The phenotypic changes that the EMT program  confers may be reversed when disseminated carcinoma cells encounter a novel microenvironment in a distant tissues, explaining the histopathologic resemblance between primary tumors and their derived metastases.

Carlo Croce, M.D., of the Ohio State University will present this lecture.

Free and open to the public. For more information, call 215-898-3944.

M. Celeste Simon, Ph.D., of the University of Pennsylvania will present this lecture.

Free and open to the public. For more information, call 215-898-3944.

Kornelia Polyak, M.D., Ph.D., of Harvard University will present this lecture.

Free and open to the public. For more information, call 215-898-3944.

Professor Giulio Cossu of University College London will present this lecture.

Free and open to the public. For more information, call 215-898-3944.

Douglas Wallace, Ph.D., of the Children’s Hospital of Philadelphia will present this lecture.

Free and open to the public. For more information, call 215-898-3944.

Murray Korc, M.D., of the Indiana University School of Medicine will present this lecture.

Free and open to the public. For more information, call 215-898-3944.

Tak Mak, Ph.D., of the University of Ontario will present this lecture.

Free and open to the public. For more information, call 215-898-3944.

Steven A. Rosenberg, M.D., Ph.D. of the NCI will present this lecture.

Free and open to the public. For more information, call 215-898-3944.

Scott Lowe, Ph.D., from Memorial-Sloan Kettering Cancer Center will present this lecture.

John Quackenbush, Ph.D., from the Dana-Farber Cancer Institute will present this lecture.

Roel Nusse, Ph.D., from Stanford University will present this lecture.

Louis M. Staudt, M.D., Ph.D., from NIH will present this lecture.

Stephen Baylin, M.D., from Johns Hopkins University will present this lecture.

Frank McCormick, Ph.D., FRS, from the University of California, San Francisco will present this lecture.

John Rinn, Ph.D. of Harvard University will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

Richard G. Pestell, M.D., Ph.D. will present this lecture.
This event is free and open to the public. For more information, call 215-898-3944.

Eric Fearon, Ph.D. of the University of Michigan will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

Robert Neil Eisenman, Ph.D. of the Fred Hutchinson Cancer Research Center will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

Perry Nisen, M.D., Ph.D. of GlaxoSmithKline will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

Jean-Pierre Issa, M.D., of Temple University will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

Eric Olson, Ph.D., of the University of Texas, will present this lecture.

This event is free and open to the public. Due to limited space, registration is required. To register, please email Maria Colelli.

Chi Van Dang, M.D., Ph.D., Director of the Abramson Cancer Center of the University of Pennsylvania, will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

Kenneth W. Kinzler, Ph.D. of Johns Hopkins University will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

Gregory J. Hannon, Ph.D. of Cold Spring Harbor Laboratory will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

Joan S. Brugge, Ph.D. of Harvard University will present this lecture.

Tumorigenesis is a clonal evolution process initiated from single cells within otherwise histologically normal tissue. How single, sporadic mutant cells that have sustained oncogenic alterations evolve within tightly regulated tissue environment remains elusive.

Dr. Brugge's laboratory has investigated the effects of inducing oncogene expression in single cells within organotypic mammary acini as a model to elucidate the processes by which oncogenic alterations initiate clonal progression from organized epithelial environments. The studies that she will present  show that initiation of outgrowth of a single oncogene-expressing cell from organized epithelial structures is a highly regulated process, and involving a cell translocation mechanism that allows sporadic mutant cells to evade suppressive microenvironments and provokes clonal selection for survival and proliferative expansion outside their native niches.

This event is free and open to the public. For more information, call 215-898-3944.

Vincent J. Cristofalo Memorial Lecture
Cancer and Aging: Rival Demons?
Judith Campisi, Ph.D.
Professor, Buck Institute for Research on Aging

Myeloid-derived Suppressor Cells as a Critical Element of Tumor Microenvironment:
Biological Role and Target for Therapeutic Intervention
Dmitry Gabrilovich, M.D., Ph.D.
H. Lee Moffitt Cancer Center & Research Institute

Computational Approaches for Predicting Transcription Factor Interactions

Mona Singh, Ph.D.
Princeton University

New Ways of Thinking About Multidrug Resistance in Cancer

George Khoury Memorial Lecture

Michael Gottesman, M.D.
Chief, Laboratory of Cell Biology, CCR, NCI, NIH

The Biology and Therapeutics of RAS and BRAF Signalling in Melanoma

Richard Marais, Ph.D., FMed Sci
Professor of Molecular Oncology
The Institute of Cancer Research

Genetic Analysis of Melanocyte Development and Its Implications for Melanoma

William Pavin, Ph.D.
Senior Investigator, NHGRI, NIH

Targeting JAK-STAT Signaling for Cancer Therapy

Richard Jove, Ph.D.
Director, Beckman Research Institute
City of Hope Cancer Center