Targeting MYC-regulated cancer cell metabolism

Targeting MYC-regulated cancer cell metabolism

Targeting MYC-regulated cancer cell metabolism

Wednesday, March 7, 2012 - 10:00am

Joseph N. Grossman, M.D. Auditorium
The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104

Chi Van Dang, M.D., Ph.D., Director of the Abramson Cancer Center of the University of Pennsylvania, will present this lecture.

This event is free and open to the public. For more information, call 215-898-3944.

The c-MYC (MYC) gene is a critical genetic hub for normal cell growth and proliferation, and its deregulated expression contributes to the genesis and maintenance of many human cancers. Since its discovery decades ago, a richer understanding of the regulation of MYC expression and the function of the Myc protein have led to a number of biological insights and cancer therapeutic opportunities.  Genome-wide studies documented the ability of Myc to induce biomass accumulation through enhanced ribosomal biogenesis, which is coupled with Myc’s induction of bioenergetics pathways involving glucose and glutamine metabolism. Tipping the balance between bioenergetics demand and supply through inhibiting critical Myc target metabolic enzymes has resulted in tangible responses in Myc-induced, fuel-addicted preclinical tumor models.