Mechanisms that regulate clonal expansion of oncogene-expressing cells in normal tissue environments

Mechanisms that regulate clonal expansion of oncogene-expressing cells in normal tissue environments

Mechanisms that regulate clonal expansion of oncogene-expressing cells in normal tissue environments

Wednesday, January 11, 2012 - 10:00am

Joseph N. Grossman, M.D. Auditorium
The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104

Joan S. Brugge, Ph.D. of Harvard University will present this lecture.

Tumorigenesis is a clonal evolution process initiated from single cells within otherwise histologically normal tissue. How single, sporadic mutant cells that have sustained oncogenic alterations evolve within tightly regulated tissue environment remains elusive.

Dr. Brugge's laboratory has investigated the effects of inducing oncogene expression in single cells within organotypic mammary acini as a model to elucidate the processes by which oncogenic alterations initiate clonal progression from organized epithelial environments. The studies that she will present  show that initiation of outgrowth of a single oncogene-expressing cell from organized epithelial structures is a highly regulated process, and involving a cell translocation mechanism that allows sporadic mutant cells to evade suppressive microenvironments and provokes clonal selection for survival and proliferative expansion outside their native niches.

This event is free and open to the public. For more information, call 215-898-3944.